Solvent and surfactant induced interactions in drug dispersions

Jarl B. Rosenholm

doi:10.1016/j.colsurfa.2009.10.009

Solvent and surfactant induced interactions in drug dispersions

Jarl B. Rosenholm^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

13 Citeringar (Scopus)

Sammanfattning

The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.

Originalspråk	Engelska
Sidor (från-till)	197-204
Antal sidor	8
Tidskrift	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volym	354
Nummer	1-3
DOI	https://doi.org/10.1016/j.colsurfa.2009.10.009
Status	Publicerad - 5 feb. 2010
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

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10.1016/j.colsurfa.2009.10.009

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@article{f820d80c35d64649acf8f644014c70b7,

title = "Solvent and surfactant induced interactions in drug dispersions",

abstract = "The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.",

keywords = "Dispersion stability, Halogenated hydrocarbons, Hamaker constant, Hydrocarbons, Particle size, Propellant liquids, Salbutamol base, Salbutamol sulphate, Solubility, Solubility parameter, ζ-Potential",

author = "Rosenholm, {Jarl B.}",

note = "Funding Information: Mr. Pasi Mikkola, MSc is thanked for providing some of the experimental results. The National Funding Agency for Technology and Innovation (TEKES) is thanked for funding. ",

year = "2010",

month = feb,

day = "5",

doi = "10.1016/j.colsurfa.2009.10.009",

language = "English",

volume = "354",

pages = "197--204",

journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

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publisher = "Elsevier",

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TY - JOUR

T1 - Solvent and surfactant induced interactions in drug dispersions

AU - Rosenholm, Jarl B.

N1 - Funding Information: Mr. Pasi Mikkola, MSc is thanked for providing some of the experimental results. The National Funding Agency for Technology and Innovation (TEKES) is thanked for funding.

PY - 2010/2/5

Y1 - 2010/2/5

N2 - The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.

AB - The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.

KW - Dispersion stability

KW - Halogenated hydrocarbons

KW - Hamaker constant

KW - Hydrocarbons

KW - Particle size

KW - Propellant liquids

KW - Salbutamol base

KW - Salbutamol sulphate

KW - Solubility

KW - Solubility parameter

KW - ζ-Potential

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U2 - 10.1016/j.colsurfa.2009.10.009

DO - 10.1016/j.colsurfa.2009.10.009

M3 - Article

AN - SCOPUS:73049113085

SN - 0927-7757

VL - 354

SP - 197

EP - 204

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

IS - 1-3

ER -

Solvent and surfactant induced interactions in drug dispersions

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