Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan; Haixia Zou; Wenhui Zhou; Xiaowan Yuan; Zhijun Li; Xiaodong Ma; Chang Liu; Yonghui Wang; Jessica M. Rosenholm; Wenguo Cui; Xiangmeng Qu; Hongbo Zhang

doi:10.1039/D2BM00640E

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan
, Haixia Zou
, Wenhui Zhou
, Xiaowan Yuan
, Zhijun Li
, Xiaodong Ma
, Chang Liu
, Yonghui Wang
, Jessica M. Rosenholm
, Wenguo Cui
, Xiangmeng Qu
, Hongbo Zhang^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

20 Citeringar (Scopus)

92 Nedladdningar (Pure)

Sammanfattning

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Originalspråk	Engelska
Sidor (från-till)	4119-4125
Antal sidor	7
Tidskrift	Biomaterials Science
Volym	10
Nummer	15
DOI	https://doi.org/10.1039/D2BM00640E
Status	Publicerad - 20 juni 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

FN:s SDG:er

Detta resultat bidrar till följande hållbara utvecklingsmål:

SDG 3 – God hälsa och välbefinnande

Åtkomst av dokument

10.1039/D2BM00640ELicens: CC BY

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy 2022Slutlig publicerad version, 2,44 MBLicens: CC BY

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Fakulteten för naturvetenskap och teknik
Utrustning/facilitet: Facilitet

FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J. (Ansvarig forskare), Xu, C. (Ansvarig forskare) & Zhang, H. (Ansvarig forskare)
Undervisnings och kulturministeriet i Finland (UKM)
01/01/21 → 31/12/24
Projekt: Ministerier / Statliga myndigheter och verk
Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Ansvarig forskare)
01/09/19 → 31/08/24
Projekt: Finlands Akademi/Övriga Forskningsråd

Citera det här

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title = "Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy",

abstract = "Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.",

author = "Jiaqi Yan and Haixia Zou and Wenhui Zhou and Xiaowan Yuan and Zhijun Li and Xiaodong Ma and Chang Liu and Yonghui Wang and Rosenholm, \{Jessica M.\} and Wenguo Cui and Xiangmeng Qu and Hongbo Zhang",

year = "2022",

month = jun,

day = "20",

doi = "10.1039/D2BM00640E",

language = "English",

volume = "10",

pages = "4119--4125",

journal = "Biomaterials Science",

issn = "2047-4849",

publisher = "Royal Society of Chemistry",

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T1 - Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

AU - Yan, Jiaqi

AU - Zou, Haixia

AU - Zhou, Wenhui

AU - Yuan, Xiaowan

AU - Li, Zhijun

AU - Ma, Xiaodong

AU - Liu, Chang

AU - Wang, Yonghui

AU - Rosenholm, Jessica M.

AU - Cui, Wenguo

AU - Qu, Xiangmeng

AU - Zhang, Hongbo

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

AB - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

U2 - 10.1039/D2BM00640E

DO - 10.1039/D2BM00640E

M3 - Article

SN - 2047-4849

VL - 10

SP - 4119

EP - 4125

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Sammanfattning

FN:s SDG:er

Åtkomst av dokument

Fingeravtryck

Utrustning

Åbo Akademi Functional Printing Center

Projekt

FCFH: Finland-China Network in Food and Health Sciences

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

Citera det här