Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan; Haixia Zou; Wenhui Zhou; Xiaowan Yuan; Zhijun Li; Xiaodong Ma; Chang Liu; Yonghui Wang; Jessica M. Rosenholm; Wenguo Cui; Xiangmeng Qu; Hongbo Zhang

doi:10.1039/D2BM00640E

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan, Haixia Zou, Wenhui Zhou, Xiaowan Yuan, Zhijun Li, Xiaodong Ma, Chang Liu, Yonghui Wang, Jessica M. Rosenholm, Wenguo Cui, Xiangmeng Qu, Hongbo Zhang^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

19 Citeringar (Scopus)

33 Nedladdningar (Pure)

Sammanfattning

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Originalspråk	Engelska
Sidor (från-till)	4119-4125
Antal sidor	7
Tidskrift	Biomaterials Science
Volym	10
Nummer	15
DOI	https://doi.org/10.1039/D2BM00640E
Status	Publicerad - 20 juni 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

FN:s SDG:er

Detta resultat bidrar till följande hållbara utvecklingsmål:

Åtkomst av dokument

10.1039/D2BM00640ELicens: CC BY

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy 2022Slutlig publicerad version, 2,44 MBLicens: CC BY

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Fakulteten för naturvetenskaper och teknik
Utrustning/facilitet: Facilitet

FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J. (Ansvarig forskare), Xu, C. (Ansvarig forskare) & Zhang, H. (Ansvarig forskare)
Undervisnings och kulturministeriet i Finland (UKM)
01/01/21 → 31/12/24
Projekt: Ministerier / Statliga myndigheter och verk
Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Ansvarig forskare)
01/09/19 → 31/08/24
Projekt: Finlands Akademi/Övriga Forskningsråd

Citera det här

@article{8478309e04cd43f4bcb4036a857de134,

title = "Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy",

abstract = "Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.",

author = "Jiaqi Yan and Haixia Zou and Wenhui Zhou and Xiaowan Yuan and Zhijun Li and Xiaodong Ma and Chang Liu and Yonghui Wang and Rosenholm, {Jessica M.} and Wenguo Cui and Xiangmeng Qu and Hongbo Zhang",

year = "2022",

month = jun,

day = "20",

doi = "10.1039/D2BM00640E",

language = "English",

volume = "10",

pages = "4119--4125",

journal = "Biomaterials Science",

issn = "2047-4849",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

AU - Yan, Jiaqi

AU - Zou, Haixia

AU - Zhou, Wenhui

AU - Yuan, Xiaowan

AU - Li, Zhijun

AU - Ma, Xiaodong

AU - Liu, Chang

AU - Wang, Yonghui

AU - Rosenholm, Jessica M.

AU - Cui, Wenguo

AU - Qu, Xiangmeng

AU - Zhang, Hongbo

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

AB - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

U2 - 10.1039/D2BM00640E

DO - 10.1039/D2BM00640E

M3 - Article

SN - 2047-4849

VL - 10

SP - 4119

EP - 4125

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Sammanfattning

FN:s SDG:er

Åtkomst av dokument

Fingeravtryck

Utrustning

Åbo Akademi Functional Printing Center

Projekt

FCFH: Finland-China Network in Food and Health Sciences

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

Citera det här