Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan, Haixia Zou, Wenhui Zhou, Xiaowan Yuan, Zhijun Li, Xiaodong Ma, Chang Liu, Yonghui Wang, Jessica M. Rosenholm, Wenguo Cui, Xiangmeng Qu, Hongbo Zhang*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

7 Citeringar (Scopus)

Sammanfattning

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.
OriginalspråkEngelska
Sidor (från-till)4119-4125
Antal sidor7
TidskriftBiomaterials Science
Volym10
Nummer15
DOI
StatusPublicerad - 20 juni 2022
MoE-publikationstypA1 Tidskriftsartikel-refererad

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