Ruthenium Catalyzed N ‐Alkylation of Cyclic Amines with Primary Alcohols

Risto Savela, Dieter Vogt, Reko Leino

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

A robust alcohol amination protocol using common saturated amines and primary alcohols as starting materials is described. The reactions are catalyzed by combination of dichloro(p-cymene)ruthenium(II) dimer precatalyst with triphenylphosphine ligand, with the excess alcohol substrate or toluene functioning as the solvent. The catalyst and ligand residues can be precipitated from the reaction media by addition of hexane or cold diethyl ether, followed by precipitation and isolation of the product as a hydrochloride salt.

OriginalspråkEngelska
Sidor (från-till)3030–3040
TidskriftEuropean Journal of Organic Chemistry
Utgåva20
DOI
StatusPublicerad - 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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