Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

L Pirkkala, P Nykänen, Lea Sistonen

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    770 Citeringar (Scopus)

    Sammanfattning

    The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival and death, In addition to extracellular stimuli, several nonstressful conditions induce Hsps during normal cellular growth and development. The enhanced heat shock gene expression in response to various stimuli is regulated by heat shock transcription factors (HSFs), After the discovery of the family of HSFs (i.e., murine and human HSF1, 2, and 4 and a unique avian HSF3), the functional relevance of distinct HSFs is now emerging. HSF1, an HSF prototype, and HSF3 are responsible for heat-induced Hsp expression, whereas HSF2 is refractory to classical stressors, HSF4 is expressed in a tissue-specific manner; similar to HSF1 and HSF2, alternatively spliced isoforms add further complexity to its regulation. Recently developed powerful genetic models have provided evidence for both cooperative and specific functions of HSFs that expand beyond the heat shock response. Certain specialized functions of HSFs may even include regulation of novel target genes in response to distinct stimuli.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)1118–1131
    Antal sidor14
    TidskriftFASEB Journal
    Volym15
    Utgåva7
    StatusPublicerad - 2001
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Nyckelord

    • heat shock element
    • HSF family
    • hsps
    • knockout and transgenic HSF models

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