Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines

Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patricia Figueiredo, Mohammad-Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni Tapio Hirvonen, Hongbo Zhang, Tongtong Chen Chen, Wenguo Cui, Yong Lu, Hélder A. Santos

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1 Citeringar (Scopus)
1 Nedladdningar (Pure)

Sammanfattning

Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as "vacosome") by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidylcholine. The vacosome triggered and enhanced bone marrow dendritic cell maturation as well as stimulated the antitumor response against breast cancer 4T1 cells in vitro. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.

OriginalspråkEngelska
Sidor (från-till)44554-44562
Antal sidor9
TidskriftACS Applied Materials and Interfaces
Volym12
Utgåva40
DOI
StatusPublicerad - 7 okt 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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