Recent advances towards mass spectrometry-based clinical lipidomics

Samira Salihovic; Santosh Lamichane; Tuulia Hyötyläinen; Matej Orešič

doi:10.1016/j.cbpa.2023.102370

Recent advances towards mass spectrometry-based clinical lipidomics

Samira Salihovic
, Santosh Lamichane
, Tuulia Hyötyläinen
, Matej Orešič^*

^*Korresponderande författare för detta arbete

Åbo biovetenskapscentrum

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

32 Citeringar (Scopus)

194 Nedladdningar (Pure)

Sammanfattning

The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging patterns in utilizing lipidomics in clinical research.In this review, we assess the recent advancements in lipidomics methodologies that exhibit high levels of selectivity and sensitivity, capable of generating numerous molecular lipid species from limited quantities of biological matrices.

The reviewed studies demonstrate that molecular lipid signatures offer new opportunities for precision medicine by providing sensitive diagnostic tools for disease prediction and monitoring. Moreover, the latest innovations in microsampling techniques have the potential to make a substantial contribution to clinical lipidomics. The review also shows that more work is needed to harmonize results across diverse lipidomics platforms and avoid significant errors in analysis and reporting. The increased implementation of internal standards and standard reference materials in analytical workflows will aid in this direction.

Originalspråk	Engelska
Artikelnummer	102370
Antal sidor	9
Tidskrift	Current Opinion in Chemical Biology
Volym	76
DOI	https://doi.org/10.1016/j.cbpa.2023.102370
Status	Publicerad - okt. 2023
MoE-publikationstyp	A2 Översiktsartikel artikel i en vetenskaplig tidskrift

Finansiering

This review preparation was supported by “Inflammation in human early life: targeting impacts on life-course health” (INITIALISE) consortium funded by the Horizon Europe Program of the European Union under Grant Agreement 101094099 (to M.O. and T.H.) and Academy of Finland (grant no. 333981 to M.O.).

Nyckelord

Biomarkers
Human health
Lipidomics
Mass spectrometry
Microsampling

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10.1016/j.cbpa.2023.102370

1-s2.0-S1367593123001084-mainSlutlig publicerad version, 882 KBLicens: CC BY

https://urn.fi/URN:NBN:fi-fe202402167471

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title = "Recent advances towards mass spectrometry-based clinical lipidomics",

abstract = "The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging patterns in utilizing lipidomics in clinical research.In this review, we assess the recent advancements in lipidomics methodologies that exhibit high levels of selectivity and sensitivity, capable of generating numerous molecular lipid species from limited quantities of biological matrices. The reviewed studies demonstrate that molecular lipid signatures offer new opportunities for precision medicine by providing sensitive diagnostic tools for disease prediction and monitoring. Moreover, the latest innovations in microsampling techniques have the potential to make a substantial contribution to clinical lipidomics. The review also shows that more work is needed to harmonize results across diverse lipidomics platforms and avoid significant errors in analysis and reporting. The increased implementation of internal standards and standard reference materials in analytical workflows will aid in this direction.",

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AU - Lamichane, Santosh

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KW - Biomarkers

KW - Human health

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KW - Mass spectrometry

KW - Microsampling

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KW - Mass spectrometry

KW - Microsampling

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Recent advances towards mass spectrometry-based clinical lipidomics

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