Ras nanoclusters: Molecular structure and assembly

Daniel Abankwa, AA Gorfe, JF Hancock

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

99 Citeringar (Scopus)

Sammanfattning

H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding proteins. Recent work has shown that Ras proteins are laterally segregated into non-overlapping, dynamic domains of the plasma membrane called nanoclusters. This lateral segregation is important to specify Ras interactions with membrane-associated proteins, effectors and scaffolding proteins and is critical for Ras signal transduction. Here we review biological, in vitro and structural data that provide insight into the molecular basis of how palmitoylated Ras proteins are anchored to the plasma membrane. We explore possible mechanisms for how the interactions of H-ras with a lipid bilayer may drive nanocluster formation. (C) 2007 Elsevier Ltd. All rights reserved.
OriginalspråkOdefinierat/okänt
Sidor (från-till)599–607
Antal sidor9
TidskriftSeminars in Cell and Developmental Biology
Volym18
Utgåva5
DOI
StatusPublicerad - 2007
MoE-publikationstypA1 Tidskriftsartikel-refererad

Nyckelord

  • lipid-raft
  • MD simulations
  • nanocluster
  • Ras
  • structure

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