QR encoded smart oral dosage forms by inkjet printing

Edinger Magnus, Bar-Shalom Daniel, Niklas Sandler, Rantanen Jukka, Genina Natalja

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

43 Citeringar (Scopus)

Sammanfattning

The use of inkjet printing (IJP) technology enables the flexible manufacturing of personalized medicine with the doses tailored for each patient. In this study we demonstrate, for the first time, the applicability of IJP in the production of edible dosage forms in the pattern of a quick response (QR) code. This printed pattern contains the drug itself and encoded information relevant to the patient and/or healthcare professionals. IJP of the active pharmaceutical ingredient (API)-containing ink in the pattern of QR code was performed onto a newly developed porous and flexible, but mechanically stable substrate with a good absorption capacity. The printing did not affect the mechanical properties of the substrate. The actual drug content of the printed dosage forms was in accordance with the encoded drug content. The QR encoded dosage forms had a good print definition without significant edge bleeding. They were readable by a smartphone even after storage in harsh conditions. This approach of efficient data incorporation and data storage combined with the use of smart devices can lead to safer and more patient-friendly drug products in the future.

OriginalspråkOdefinierat/okänt
Sidor (från-till)138–145
TidskriftInternational Journal of Pharmaceutics
Volym536
Utgåva1
DOI
StatusPublicerad - 2018
MoE-publikationstypA1 Tidskriftsartikel-refererad

Nyckelord

  • Personalized medicine
  • Smartphone
  • Inkjet printing
  • Oral dosage forms
  • QR code
  • Haloperidol

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