Predicted Hotspot Residues Involved in Allosteric Signal Transmission in Pro-Apoptotic Peptide-Mcl1 Complexes

Keyphrases

• Amino Acid Sequence 20%
• Amphipathic Helix 20%
• Apoptotic Regulation 20%
• B-cell Lymphoma 2 (Bcl-2) 20%
• Cancer Pathology 20%
• Dynamic Network Analysis 20%
• Energy Component 20%
• Energy Terms 20%
• Generalized Born 20%
• Heterodimerization 20%
• Hotspot Residues 100%
• Hydrophobic Binding 20%
• Molecular Mechanics 20%
• Multiple Parameters 20%
• Myeloid Cell leukemia-1 (Mcl-1) 100%
• Novel Peptide 40%
• Organic Inhibitor 20%
• Partner Selectivity 20%
• Peptide Targeting 20%
• Pro-apoptotic Peptide 100%
• Regulatory Process 20%
• Sequence Variation 20%
• Signal Transmission 100%
• Small Organic Molecules 20%
• Transmission Route 20%
• WaaL 20%

Chemistry

• Amino Acid Sequence 16%
• Apoptotic 100%
• Calorific Value 16%
• Gibbs Free Energy 50%
• Heterodimerization 16%
• Molecular Mechanic 16%
• Organic Molecule 16%
• Primary Structure 16%

Biochemistry, Genetics and Molecular Biology

• Dynamics 50%
• Peptide Sequence 50%
• Signal Transduction 100%
• Static Electricity 50%