Precipitation of Inorganic Salts in Mitochondrial Matrix

Jerzy J. Jasielec, Robert Filipek, Krzysztof Dołowy, Andrzej Lewenstam

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    2 Citeringar (Scopus)

    Sammanfattning

    In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke.
    OriginalspråkEngelska
    TidskriftMembranes
    Volym10
    Utgåva5
    DOI
    StatusPublicerad - 2020
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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