PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity

Mohd Moin Khan; Ubaid Ullah Kalim; Meraj H. Khan; Riitta Lahesmaa

doi:10.3389/fimmu.2021.786857

PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity

Mohd Moin Khan
, Ubaid Ullah Kalim
, Meraj H. Khan
, Riitta Lahesmaa^*

^*Korresponderande författare för detta arbete

Åbo biovetenskapscentrum

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

25 Citeringar (Scopus)

93 Nedladdningar (Pure)

Sammanfattning

Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.

Originalspråk	Engelska
Artikelnummer	786857
Tidskrift	Frontiers in Immunology
Volym	12
DOI	https://doi.org/10.3389/fimmu.2021.786857
Status	Publicerad - 5 jan. 2022
MoE-publikationstyp	A2 Översiktsartikel artikel i en vetenskaplig tidskrift

Finansiering

MMK was supported by the University of Turku graduate school on Turku Doctoral Programme of Molecular Medicine (TuDMM) and a central grant from the Finnish Cultural Foundation. UK was supported by Varsinais-Suomi regional Fund from Finnish Cultural Foundation. RL was supported by the Academy of Finland, AoF, Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) grant 250114; by the AoF grants 292335, 294337, 292482, 31444, 335435, 331793, 329277, and by grants from the JDRF, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation and the Finnish Cancer Foundation.

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10.3389/fimmu.2021.786857

PP2A and Its Inhibitors in Helper T-Cell Differentiation and AutoimmunitySlutlig publicerad version, 919 KBLicens: CC BY

https://urn.fi/URN:NBN:fi-fe2023022228221

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abstract = "Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.",

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note = "Funding Information: MMK was supported by the University of Turku graduate school on Turku Doctoral Programme of Molecular Medicine (TuDMM) and a central grant from the Finnish Cultural Foundation. UK was supported by Varsinais-Suomi regional Fund from Finnish Cultural Foundation. RL was supported by the Academy of Finland, AoF, Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) grant 250114; by the AoF grants 292335, 294337, 292482, 31444, 335435, 331793, 329277, and by grants from the JDRF, the Sigrid Jus{\'e}lius Foundation, the Jane and Aatos Erkko Foundation and the Finnish Cancer Foundation. Publisher Copyright: Copyright {\textcopyright} 2022 Khan, Kalim, Khan and Lahesmaa.",

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AU - Khan, Meraj H.

AU - Lahesmaa, Riitta

N1 - Funding Information: MMK was supported by the University of Turku graduate school on Turku Doctoral Programme of Molecular Medicine (TuDMM) and a central grant from the Finnish Cultural Foundation. UK was supported by Varsinais-Suomi regional Fund from Finnish Cultural Foundation. RL was supported by the Academy of Finland, AoF, Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) grant 250114; by the AoF grants 292335, 294337, 292482, 31444, 335435, 331793, 329277, and by grants from the JDRF, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation and the Finnish Cancer Foundation. Publisher Copyright: Copyright © 2022 Khan, Kalim, Khan and Lahesmaa.

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N2 - Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.

AB - Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.

KW - autoimmune disease

KW - inflammatory

KW - PP2A

KW - PP2A activating drugs

KW - T cell differentiation

UR - https://www.scopus.com/pages/publications/85123074496

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DO - 10.3389/fimmu.2021.786857

M3 - Review Article or Literature Review

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AN - SCOPUS:85123074496

SN - 1664-3224

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 786857

ER -

PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity

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