TY - JOUR
T1 - Physical Activity in Preventing Alzheimer’s Disease and Cognitive Decline: A Narrative Review
AU - Brini, Stefano
AU - Sohrabi, Hamid R.
AU - Peiffer, Jeremiah J.
AU - Karrasch, Mira
AU - Hämäläinen, Heikki
AU - Martins, Ralph N.
AU - Fairchild, Timothy J.
PY - 2017
Y1 - 2017
N2 - A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer's disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations. The interaction between PA and the putative mechanisms underlying AD progression, including genetic factors and amyloid-beta levels will be explored. In this context, particular attention will be given to studies assessing PA in the early clinical and preclinical, asymptomatic stages of AD. Based on current evidence, clinical considerations for implementation of exercise-based interventions are discussed, along with limitations of previous research and directions for future studies.
AB - A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer's disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations. The interaction between PA and the putative mechanisms underlying AD progression, including genetic factors and amyloid-beta levels will be explored. In this context, particular attention will be given to studies assessing PA in the early clinical and preclinical, asymptomatic stages of AD. Based on current evidence, clinical considerations for implementation of exercise-based interventions are discussed, along with limitations of previous research and directions for future studies.
U2 - 10.1007/s40279-017-0787-y
DO - 10.1007/s40279-017-0787-y
M3 - Översiktsartikel
SN - 0112-1642
VL - 48
SP - 29
EP - 44
JO - Sports Medicine
JF - Sports Medicine
IS - 1
ER -