Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

Martina Stekrova; Narendra Kumar; Päivi Mäki-Arvela; Atte Aho; Johan Linden; Konstantin P. Volcho; Nariman F. Salakhutdinov; Dmitry Yu Murzin

doi:10.1007/s11144-013-0615-9

Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

Martina Stekrova
, Narendra Kumar
, Päivi Mäki-Arvela
, Atte Aho
, Johan Linden
, Konstantin P. Volcho
, Nariman F. Salakhutdinov
, Dmitry Yu Murzin^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

17 Citeringar (Scopus)

Sammanfattning

High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO₂ to Al2O₃ ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

Originalspråk	Engelska
Sidor (från-till)	449-458
Antal sidor	10
Tidskrift	Reaction Kinetics, Mechanisms and Catalysis
Volym	110
Nummer	2
DOI	https://doi.org/10.1007/s11144-013-0615-9
Status	Publicerad - aug. 2013
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

Acknowledgments This work is part of the activities at the Åbo Akademi University, Process Chemistry Centre within the Finnish Centre of Excellence Program appointed by the Academy of Finland. The publication was supported by the UniCRE project, funded by the EU Structural Funds and the state budget of the Czech Republic.

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title = "Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts",

abstract = "High selectivity (82 \%) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 \% in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Br{\o}nsted and Lewis acid sites.",

keywords = "Isomerization, Mesoporous material, Verbenol oxide, Zeolite",

author = "Martina Stekrova and Narendra Kumar and P{\"a}ivi M{\"a}ki-Arvela and Atte Aho and Johan Linden and Volcho, \{Konstantin P.\} and Salakhutdinov, \{Nariman F.\} and Murzin, \{Dmitry Yu\}",

year = "2013",

month = aug,

doi = "10.1007/s11144-013-0615-9",

language = "English",

volume = "110",

pages = "449--458",

journal = "Reaction Kinetics, Mechanisms and Catalysis",

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T1 - Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

AU - Stekrova, Martina

AU - Kumar, Narendra

AU - Mäki-Arvela, Päivi

AU - Aho, Atte

AU - Linden, Johan

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

AU - Murzin, Dmitry Yu

PY - 2013/8

Y1 - 2013/8

N2 - High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

AB - High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene- 1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.

KW - Isomerization

KW - Mesoporous material

KW - Verbenol oxide

KW - Zeolite

UR - https://www.scopus.com/pages/publications/84893707379

U2 - 10.1007/s11144-013-0615-9

DO - 10.1007/s11144-013-0615-9

M3 - Article

AN - SCOPUS:84893707379

SN - 1878-5190

VL - 110

SP - 449

EP - 458

JO - Reaction Kinetics, Mechanisms and Catalysis

JF - Reaction Kinetics, Mechanisms and Catalysis

IS - 2

ER -

Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts

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