One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Päivi Mäki-Arvela; Serap Sahin; Narendra Kumar; Jyri-Pekka Mikkola; Kari Eränen; Tapio Salmi; Dmitry Yu. Murzin

doi:10.1016/j.cattod.2008.07.037

One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Päivi Mäki-Arvela, Serap Sahin, Narendra Kumar, Jyri-Pekka Mikkola, Kari Eränen, Tapio Salmi, Dmitry Yu. Murzin^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

14 Citeringar (Scopus)

Sammanfattning

One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al₂O₃, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

Originalspråk	Engelska
Sidor (från-till)	70-73
Antal sidor	4
Tidskrift	Catalysis Today
Volym	140
Nummer	1-2
DOI	https://doi.org/10.1016/j.cattod.2008.07.037
Status	Publicerad - 15 feb. 2009
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Åtkomst av dokument

10.1016/j.cattod.2008.07.037Licens: Publisher rights policy

Andra filer och länkar

Länk till publikationen i Scopus

Citera det här

@article{66d9d7a1a01f43a0add0cf245fb87596,

title = "One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone",

abstract = "One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.",

keywords = "Acylation, Heterogeneous catalyst, Hydrogenation, One-pot synthesis",

author = "P{\"a}ivi M{\"a}ki-Arvela and Serap Sahin and Narendra Kumar and Jyri-Pekka Mikkola and Kari Er{\"a}nen and Tapio Salmi and Murzin, {Dmitry Yu.}",

year = "2009",

month = feb,

day = "15",

doi = "10.1016/j.cattod.2008.07.037",

language = "English",

volume = "140",

pages = "70--73",

journal = "Catalysis Today",

issn = "0920-5861",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - One-pot utilization of heterogeneous and enzymatic catalysis

T2 - Synthesis of R-1-phenylethyl acetate from acetophenone

AU - Mäki-Arvela, Päivi

AU - Sahin, Serap

AU - Kumar, Narendra

AU - Mikkola, Jyri-Pekka

AU - Eränen, Kari

AU - Salmi, Tapio

AU - Murzin, Dmitry Yu.

PY - 2009/2/15

Y1 - 2009/2/15

N2 - One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

AB - One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

KW - Acylation

KW - Heterogeneous catalyst

KW - Hydrogenation

KW - One-pot synthesis

UR - http://www.scopus.com/inward/record.url?scp=57849130271&partnerID=8YFLogxK

U2 - 10.1016/j.cattod.2008.07.037

DO - 10.1016/j.cattod.2008.07.037

M3 - Article

AN - SCOPUS:57849130271

SN - 0920-5861

VL - 140

SP - 70

EP - 73

JO - Catalysis Today

JF - Catalysis Today

IS - 1-2

ER -

One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Sammanfattning

Åtkomst av dokument

Andra filer och länkar

Fingeravtryck

Citera det här