One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Päivi Mäki-Arvela, Serap Sahin, Narendra Kumar, Jyri-Pekka Mikkola, Kari Eränen, Tapio Salmi, Dmitry Yu. Murzin*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

13 Citeringar (Scopus)

Sammanfattning

One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

OriginalspråkEngelska
Sidor (från-till)70-73
Antal sidor4
TidskriftCatalysis Today
Volym140
Utgåva1-2
DOI
StatusPublicerad - 15 feb 2009
MoE-publikationstypA1 Tidskriftsartikel-refererad

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