TY - JOUR
T1 - Nuclear stress granules
T2 - the awakening of a sleeping beauty?
AU - Sandqvist, Anton
AU - Sistonen, Lea
PY - 2004/1/5
Y1 - 2004/1/5
N2 - Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites, a heterochromatic region that has been considered silent (Jolly et al., 2004). These intriguing findings will certainly give the research of these structures a new twist.
AB - Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites, a heterochromatic region that has been considered silent (Jolly et al., 2004). These intriguing findings will certainly give the research of these structures a new twist.
KW - Animals
KW - Cell Nucleus Structures/genetics
KW - Chromosomes, Human, Pair 9/genetics
KW - DNA, Satellite/genetics
KW - DNA-Binding Proteins/genetics
KW - Heat Shock Transcription Factors
KW - Heterochromatin/genetics
KW - Humans
KW - RNA Precursors/genetics
KW - Stress, Physiological/genetics
KW - Transcription Factors
KW - Transcriptional Activation/genetics
U2 - 10.1083/jcb.200311102
DO - 10.1083/jcb.200311102
M3 - Review Article or Literature Review
C2 - 14709538
SN - 0021-9525
VL - 164
SP - 15
EP - 17
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 1
ER -