New nucleoside analogs from 2-amino-9-(β-D-ribofuranosyl)purine

P Virta, T Holmström, MU Roslund, Peter Mattjus, Leif Kronberg, R Sjöholm

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    9 Citeringar (Scopus)

    Sammanfattning

    Four novel derivatives of 2-amino-9-(beta-D-ribofuranosyl) purine ( 1) were synthesised and fully characterised. When 1 was reacted with chloroacetaldehyde (a), 2-chloropropanal (b), bromomalonaldehyde (c) and a mixture of chloroacetaldehyde + malonaldehyde (d), 3-(beta-D-ribofuranosyl)- imidazo-[1,2a] purine (2), 3-(beta-D-ribofuranosyl)-5- methylimidazo-[1,2a] purine (3), 3-(beta-D-ribofuranosyl)-5-formylimidazo-[1,2a] purine (4) and 9-(beta-D-ribofuranosyl)-2-( 3,5-diformyl-4-methyl-1,4-dihydro-1-pyridyl) purine (5) were formed, respectively. The products were isolated, purified by chromatography and characterised by MS, complete NMR assignment as well as fluorescence and UV spectroscopy. The yields of these reactions were moderate ( 14 - 20%). The fluorescence properties differed from those of the starting compound and the quantum yields were considerably lower.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)821–827
    Antal sidor7
    TidskriftOrganic and Biomolecular Chemistry
    Volym2
    Utgåva6
    DOI
    StatusPublicerad - 2004
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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