New nucleoside analogs from 2-amino-9-(β-D-ribofuranosyl)purine

P Virta, T Holmström, MU Roslund, Peter Mattjus, Leif Kronberg, R Sjöholm

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    9 Citeringar (Scopus)


    Four novel derivatives of 2-amino-9-(beta-D-ribofuranosyl) purine ( 1) were synthesised and fully characterised. When 1 was reacted with chloroacetaldehyde (a), 2-chloropropanal (b), bromomalonaldehyde (c) and a mixture of chloroacetaldehyde + malonaldehyde (d), 3-(beta-D-ribofuranosyl)- imidazo-[1,2a] purine (2), 3-(beta-D-ribofuranosyl)-5- methylimidazo-[1,2a] purine (3), 3-(beta-D-ribofuranosyl)-5-formylimidazo-[1,2a] purine (4) and 9-(beta-D-ribofuranosyl)-2-( 3,5-diformyl-4-methyl-1,4-dihydro-1-pyridyl) purine (5) were formed, respectively. The products were isolated, purified by chromatography and characterised by MS, complete NMR assignment as well as fluorescence and UV spectroscopy. The yields of these reactions were moderate ( 14 - 20%). The fluorescence properties differed from those of the starting compound and the quantum yields were considerably lower.
    Sidor (från-till)821–827
    Antal sidor7
    TidskriftOrganic and Biomolecular Chemistry
    StatusPublicerad - 2004
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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