Network analytics for drug repurposing in COVID-19

Nicoleta Siminea, Victor Popescu, Jose Angel Sanchez Martin, Daniela Florea, Georgiana Gavril, Ana-Maria Gheorghe, Corina Iţcuş, Krishna Kanhaiya, Octavian Pacioglu, Laura Ioana Popa, Romica Trandafir, Maria Iris Tusa, Manuela Sidoroff, Mihaela Pãun, Eugen Czeizler, Andrei Pãun, Ion Petre*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

16 Citeringar (Scopus)
17 Nedladdningar (Pure)

Sammanfattning

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.

OriginalspråkEngelska
Artikelnummerbbab490
TidskriftBriefings in Bioinformatics
Volym23
Nummer1
DOI
StatusPublicerad - 1 jan. 2022
MoE-publikationstypA1 Tidskriftsartikel-refererad

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