Multisite phosphorylation provides sophisticated regulation of transcription factors

CI Holmberg, Tran SEF, John Eriksson, Lea Sistonen

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    104 Citeringar (Scopus)

    Sammanfattning

    Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in the cellular environment. Accumulated evidence has expanded the concept of phosphorylation to a process that provides dynamic and precise tuning of the transactivating potential of a factor, rather than being a static on/off switch. In the case of transcription factors such as heat shock factor 1 (HSF1), p53 and nuclear factor of activated T cells (NFAT), multisite phosphorylation enables several effects to operate within a single factor, thereby functioning as a key to signal integration. Studies on these transcription factors illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)619–627
    Antal sidor9
    TidskriftTrends in Biochemical Sciences
    Volym27
    Utgåva12
    StatusPublicerad - 2002
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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