TY - JOUR
T1 - Molecular Mechanisms of Heat Shock Factors in Cancer
AU - Puustinen, Mikael Christer
AU - Sistonen, Lea
PY - 2020
Y1 - 2020
N2 - Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed.
AB - Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed.
KW - Animals
KW - Heat-Shock Proteins/metabolism
KW - Humans
KW - Models, Biological
KW - Neoplasm Invasiveness
KW - Neoplasms/chemistry
KW - Protein Domains
U2 - 10.3390/cells9051202
DO - 10.3390/cells9051202
M3 - Review Article or Literature Review
C2 - 32408596
SN - 2073-4409
VL - 9
JO - Cells
JF - Cells
IS - 5
M1 - 1202
ER -