Microwave-assisted synthesis, characterization and modeling of CPO-27-Mg metal-organic framework for drug delivery

Anton I. Kudelin, Konstantinos Papathanasiou, Vera Isaeva, Juergen Caro, Tapio Salmi, Leonid M. Kustov

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

4 Citeringar (Scopus)

Sammanfattning

The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions.
OriginalspråkEngelska
Artikelnummer426
Antal sidor9
TidskriftMolecules
Volym26
Nummer2
DOI
StatusPublicerad - 15 jan. 2021
MoE-publikationstypA1 Tidskriftsartikel-refererad

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