Menthylamine synthesis via gold-catalyzed hydrogenation of menthone oxime

Yu S. Demidova, E. S. Mozhaitsev, E. V. Suslov, A. A. Nefedov, A. A. Saraev, K. P. Volcho, N. F. Salakhutdinov, A. Simakov, I. L. Simakova*, D. Yu Murzin

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

In the current work gold nanoparticles supported on oxides (MgO, Al2O3, ZrO2, TiO2) were used for menthylamine synthesis via menthone oxime hydrogenation. An increase of the gold nanoparticles size and application of metal oxides with a strong basic character such as magnesia favored deoximation to menthone. Au/Al2O3 catalyst with the gold nanoparticles size of 2.0 nm afforded high catalytic activity and selectivity to menthylamine. The reaction kinetics including stereoselectivity to the reaction products and recyclability of the catalyst was studied using Au/Al2O3 in the temperature range 90−110 °C under hydrogen pressure of 5.5–7.5 bar. The catalytic behavior was influenced by the solvent nature, with higher selectivity to desired amine achieved using methanol. The reaction rate was pressure independent, while has first order with respect to menthone oxime concentration. Stereoselectivity to menthylamines and menthones was independent on the reaction temperature and the hydrogen pressure.

OriginalspråkEngelska
Artikelnummer117799
TidskriftApplied Catalysis A: General
Volym605
DOI
StatusPublicerad - 5 sep 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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