Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Krister Karlsson; Vesa Sipiä; Harri Kankaanpää; Jussi Meriluoto

doi:10.1016/S1570-0232(02)00802-4

Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Krister Karlsson
, Vesa Sipiä
, Harri Kankaanpää
, Jussi Meriluoto^*

^*Korresponderande författare för detta arbete

Laboratoryservices

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

56 Citeringar (Scopus)

Sammanfattning

Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

Originalspråk	Engelska
Sidor (från-till)	243-253
Antal sidor	11
Tidskrift	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volym	784
Nummer	2
DOI	https://doi.org/10.1016/S1570-0232(02)00802-4
Status	Publicerad - 5 feb. 2003
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

We wish to thank the Academy of Finland for financial support (RC for Natural Sciences and Engineering, project 47664 of J.M. and K.K., and RC for Biosciences and Environment, project 48019 of V.S.). K.K. also acknowledges the support from the National Graduate School of Informational and Structural Biology and the Magnus Ehrnrooth Foundation.

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title = "Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders",

abstract = "Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.",

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AU - Karlsson, Krister

AU - Sipiä, Vesa

AU - Kankaanpää, Harri

AU - Meriluoto, Jussi

N1 - Funding Information: We wish to thank the Academy of Finland for financial support (RC for Natural Sciences and Engineering, project 47664 of J.M. and K.K., and RC for Biosciences and Environment, project 48019 of V.S.). K.K. also acknowledges the support from the National Graduate School of Informational and Structural Biology and the Magnus Ehrnrooth Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

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N2 - Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

AB - Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

KW - Desmethylnodularin

KW - Flounder

KW - Mussel

KW - Nodularin

UR - https://www.scopus.com/pages/publications/0346036082

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JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

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Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

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