TY - JOUR
T1 - Luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus Metapochonia lutea.
AU - Labuda, Roman
AU - Bacher, Markus
AU - Gratzl, Hannes
AU - Doppler, Maria
AU - Parich, Alexandra
AU - Aufy, Mohammed
AU - Lemmens-Gruber, Rosa
AU - Schuhmacher, Rainer
AU - Rychli, Kathrin
AU - Wagner, Martin
AU - Rosenau, Thomas
AU - Strauss, Joseph
AU - Schüller, Christoph
N1 - Funding Information:
Funding: The research platform Bioactive Microbial Metabolites (BiMM) is supported by grants K3-G-2/026-2013 and COMBIS/ LS16005 funded by the Gesellschaft für Forschungsförderung Nie-derösterreich m.b.H.
Publisher Copyright:
© 2021 Licensee MDPI, Basel, Switzerland.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - In the process of screening for new bioactive microbial metabolites we found a novel ƴpyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).
AB - In the process of screening for new bioactive microbial metabolites we found a novel ƴpyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).
KW - Actinopyrones
KW - Fungal metabolites
KW - Verticillium-like species
KW - Verticipyrone
UR - http://www.scopus.com/inward/record.url?scp=85118412986&partnerID=8YFLogxK
U2 - 10.3390/molecules26216589
DO - 10.3390/molecules26216589
M3 - Article
C2 - 34770997
AN - SCOPUS:85118412986
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 21
M1 - 6589
ER -