Long-term outcome after allogeneic stem cell transplantation in multiple myeloma

Sini Luoma*, Raija Silvennoinen, Auvo Rauhala, Riitta Niittyvuopio, Eeva Martelin, Vesa Lindström, Jouni Heiskanen, Liisa Volin, Tapani Ruutu, Anne Nihtinen

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1 Citeringar (Scopus)

Sammanfattning

The role of allogeneic hematopoietic stem cell transplantation (allo-SCT) in multiple myeloma is controversial. We analyzed the results of 205 patients transplanted in one center during 2000–2017. Transplantation was performed on 75 patients without a previous autologous SCT (upfront-allo), on 74 as tandem transplant (auto-allo), and on 56 patients after relapse. Median overall survival (OS) was 9.9 years for upfront-allo, 11.2 years for auto-allo, and 3.9 years for the relapse group (p = 0.015). Progression-free survival (PFS) was 2.4, 2.4, and 0.9 years, respectively (p < 0.001). Non-relapse mortality at 5 years was 8% overall, with no significant difference between the groups. Post-relapse survival was 4.1 years for upfront-allo and auto-allo, and 2.6 years for the relapse group (p = 0.066). Survival of high-risk patients was reduced. In multivariate analysis, the auto-allo group had improved OS and chronic graft-versus-host disease was advantageous in terms of PFS, OS, and relapse incidence. Late relapses occurred in all groups. Allo-SCT resulted in long-term survival in a small subgroup of patients. Our results indicate that auto-allo-SCT is feasible and could be considered for younger patients in the upfront setting.

OriginalspråkEngelska
Sidor (från-till)1553-1567
Antal sidor15
TidskriftAnnals of Hematology
Volym100
Utgåva6
DOI
StatusPublicerad - jun 2021
MoE-publikationstypA1 Tidskriftsartikel-refererad

Nyckelord

  • myelom

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