Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers

Lucia Sarcina; Fabrizio Viola; Francesco Modena; Paolo Bollella; Mario Caironi; Irene Esposito; Luisa Torsi; Fabrizio Torricelli; Eleonora MacChia

doi:10.1109/FLEPS53764.2022.9781550

Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers

Lucia Sarcina
, Fabrizio Viola
, Francesco Modena
, Paolo Bollella
, Mario Caironi
, Irene Esposito
, Luisa Torsi
, Fabrizio Torricelli^*
, Eleonora MacChia

^*Korresponderande författare för detta arbete

Fysik

Forskningsoutput: Kapitel i bok/konferenshandling › Publicerad konferensartikel › Vetenskaplig › Peer review

3 Citeringar (Scopus)

Sammanfattning

Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the "Single-Molecule assay with a large Transistor"(SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.

Originalspråk	Engelska
Titel på värdpublikation	2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)
Förlag	the Institute of Electrical and Electronics Engineers, Inc.
ISBN (elektroniskt)	9781665442732
DOI	https://doi.org/10.1109/FLEPS53764.2022.9781550
Status	Publicerad - 2022
MoE-publikationstyp	A4 Artikel i en konferenspublikation
Evenemang	2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022 - Vienna, Österrike Varaktighet: 10 juli 2022 → 13 juli 2022

Publikationsserier

Namn	FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings

Konferens

Konferens	2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022
Land/Territorium	Österrike
Ort	Vienna
Period	10/07/22 → 13/07/22

Finansiering

ACKNOWLEDGMENT The projects: SiMBiT—Single molecule bioelectronic smart system array for clinical testing (Grant Agreement ID: 824946), Dottorati innovativi con caratterizzazione industrial—PON R&I 2014–2020 “Sensore bio-elettronico usa-e-getta per l’HIV autoalimentato da una cella a combustibile biologica”, Academy of Finland #332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagnosis,”, Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell’HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020, “GREENELIT” under the EU H2020 research and innovation programme - Twinning of research institutions (Grant agreement ID: 951747), Åbo Akademi University CoE “Bioelectronic activation of cell functions” and CSGI are acknowledged for partial financial support. The fabrication of the EG-OFETs was partially carried out at PoliFab, the micro and nano-technology center of the Politecnico di Milano.

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10.1109/FLEPS53764.2022.9781550

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Sarcina, L., Viola, F., Modena, F., Bollella, P., Caironi, M., Esposito, I., Torsi, L., Torricelli, F., & MacChia, E. (2022). Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers. I 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS) Artikel 21971846 (FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings). the Institute of Electrical and Electronics Engineers, Inc.. https://doi.org/10.1109/FLEPS53764.2022.9781550

Sarcina, Lucia ; Viola, Fabrizio ; Modena, Francesco et al. / Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers. 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS). the Institute of Electrical and Electronics Engineers, Inc., 2022. (FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings).

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title = "Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers",

abstract = "Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the {"}Single-Molecule assay with a large Transistor{"}(SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.",

keywords = "3D printing, biosensors, single-molecule, SPR",

author = "Lucia Sarcina and Fabrizio Viola and Francesco Modena and Paolo Bollella and Mario Caironi and Irene Esposito and Luisa Torsi and Fabrizio Torricelli and Eleonora MacChia",

note = "BOF 15/1 EK Funding Information: ACKNOWLEDGMENT The projects: SiMBiT—Single molecule bioelectronic smart system array for clinical testing (Grant Agreement ID: 824946), Dottorati innovativi con caratterizzazione industrial—PON R\&I 2014–2020 “Sensore bio-elettronico usa-e-getta per l{\textquoteright}HIV autoalimentato da una cella a combustibile biologica”, Academy of Finland \#332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagnosis,”, Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell{\textquoteright}HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020, “GREENELIT” under the EU H2020 research and innovation programme - Twinning of research institutions (Grant agreement ID: 951747), {\AA}bo Akademi University CoE “Bioelectronic activation of cell functions” and CSGI are acknowledged for partial financial support. The fabrication of the EG-OFETs was partially carried out at PoliFab, the micro and nano-technology center of the Politecnico di Milano. Publisher Copyright: {\textcopyright} 2022 IEEE.; 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022 ; Conference date: 10-07-2022 Through 13-07-2022",

year = "2022",

doi = "10.1109/FLEPS53764.2022.9781550",

language = "English",

series = "FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings",

publisher = "the Institute of Electrical and Electronics Engineers, Inc.",

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Sarcina, L, Viola, F, Modena, F, Bollella, P, Caironi, M, Esposito, I, Torsi, L, Torricelli, F & MacChia, E 2022, Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers. i 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)., 21971846 , FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings, the Institute of Electrical and Electronics Engineers, Inc., 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022, Vienna, Österrike, 10/07/22. https://doi.org/10.1109/FLEPS53764.2022.9781550

Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers. / Sarcina, Lucia; Viola, Fabrizio; Modena, Francesco et al.
2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS). the Institute of Electrical and Electronics Engineers, Inc., 2022. 21971846 (FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings).

Forskningsoutput: Kapitel i bok/konferenshandling › Publicerad konferensartikel › Vetenskaplig › Peer review

TY - GEN

T1 - Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers

AU - Sarcina, Lucia

AU - Viola, Fabrizio

AU - Modena, Francesco

AU - Bollella, Paolo

AU - Caironi, Mario

AU - Esposito, Irene

AU - Torsi, Luisa

AU - Torricelli, Fabrizio

AU - MacChia, Eleonora

N1 - BOF 15/1 EK Funding Information: ACKNOWLEDGMENT The projects: SiMBiT—Single molecule bioelectronic smart system array for clinical testing (Grant Agreement ID: 824946), Dottorati innovativi con caratterizzazione industrial—PON R&I 2014–2020 “Sensore bio-elettronico usa-e-getta per l’HIV autoalimentato da una cella a combustibile biologica”, Academy of Finland #332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagnosis,”, Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell’HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020, “GREENELIT” under the EU H2020 research and innovation programme - Twinning of research institutions (Grant agreement ID: 951747), Åbo Akademi University CoE “Bioelectronic activation of cell functions” and CSGI are acknowledged for partial financial support. The fabrication of the EG-OFETs was partially carried out at PoliFab, the micro and nano-technology center of the Politecnico di Milano. Publisher Copyright: © 2022 IEEE.

PY - 2022

Y1 - 2022

N2 - Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the "Single-Molecule assay with a large Transistor"(SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.

AB - Pancreatic-biliary cancer represents a challenge for clinicians since the detection is performed at later stages and treated with palliative approaches. A screening method for the early detection should be of paramount importance. The aim of this study is the detection of pancreatic mucinous cysts protein markers (MUC1) in human serum down to the physical limit, using an Electrolyte-gated FET based technology, namely the "Single-Molecule assay with a large Transistor"(SiMoT) platform. The structure and transistor components have been developed on plastic substrates. The 3D gate structure is compatible with an ELISA plate. The functionalization procedure is assessed independently through Surface Plasmon Resonance, enabling the real-time monitoring of the gold modification with antibodies essential for the assay.

KW - 3D printing

KW - biosensors

KW - single-molecule

KW - SPR

UR - https://www.scopus.com/pages/publications/85137170763

U2 - 10.1109/FLEPS53764.2022.9781550

DO - 10.1109/FLEPS53764.2022.9781550

M3 - Published conference proceeding

AN - SCOPUS:85137170763

T3 - FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings

BT - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)

PB - the Institute of Electrical and Electronics Engineers, Inc.

T2 - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022

Y2 - 10 July 2022 through 13 July 2022

ER -

Sarcina L, Viola F, Modena F, Bollella P, Caironi M, Esposito I et al. Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers. I 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS). the Institute of Electrical and Electronics Engineers, Inc. 2022. 21971846 . (FLEPS 2022 - IEEE International Conference on Flexible and Printable Sensors and Systems, Proceedings). doi: 10.1109/FLEPS53764.2022.9781550

Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers

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