Kinetic modeling of lipase-mediated one-pot chemo-bio cascade synthesis of R-1-phenyl ethyl acetate starting from acetophenone

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

6 Citeringar (Scopus)

Sammanfattning

BACKGROUND: A systematic investigation of mutual interference between a hydrogenation catalyst, Pd/Al2O3, and an immobilized lipase in a one-pot synthesis of R-1-phenyl ethyl acetate at 70 °C has been undertaken. This paper reports the kinetic modeling of lipase-mediated chemo-bio cascade synthesis of R-1-phenyl ethyl acetate starting from acetophenone. RESULTS: The kinetic results revealed that these catalysts were not acting independently but in concert. A mechanism which predicts the experimental observations for this reaction is proposed. CONCLUSION: The parameters of the kinetic model, which are in good agreement with the experimental data, were estimated through numerical data fitting. The reliability of the estimated parameters was analyzed using the Markov Chain Monte Carlo (MCMC) method.

OriginalspråkEngelska
Sidor (från-till)192-198
Antal sidor7
TidskriftJournal of Chemical Technology and Biotechnology
Volym85
Utgåva2
DOI
StatusPublicerad - feb 2010
MoE-publikationstypA1 Tidskriftsartikel-refererad

Fingeravtryck

Fördjupa i forskningsämnen för ”Kinetic modeling of lipase-mediated one-pot chemo-bio cascade synthesis of R-1-phenyl ethyl acetate starting from acetophenone”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här