Keratins in health and disease

Diana Toivola, P. BOOR, Catharina Alam, P STRNAD

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

105 Citeringar (Scopus)

Sammanfattning

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and their inherited and spontaneous mutations give rise to keratinopathies. For example, mutations in K1/K5/K10/K14 cause epidermal skin diseases whereas simple epithelial K8/K18/K19 variants predispose to development of several liver disorders. Due to their abundance, tissue- and context-specific expression, keratins constitute excellent diagnostic markers of both neoplastic and non-neoplastic diseases. During injury and in disease, keratin expression levels, cellular localization or posttranslational modifications are altered. Accumulating evidence suggests that these changes modulate multiple processes including cell migration, tumor growth/metastasis and development of infections. Therefore, our understanding of keratins is shifting from diagnostic markers to active disease modifiers.
OriginalspråkOdefinierat/okänt
Sidor (från-till)73–81
TidskriftCurrent Opinion in Cell Biology
Volym32
DOI
StatusPublicerad - 2015
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Nyckelord

  • keratin
  • human mutations
  • disease

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