TY - JOUR
T1 - Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticles
AU - Wang, Qingbo
AU - Xu, Wenyang
AU - Koppolu, Rajesh
AU - van Bochove, Bas
AU - Seppälä, Jukka
AU - Hupa, Leena
AU - Willför, Stefan
AU - Xu, Chunlin
AU - Wang, Xiaoju
N1 - Funding Information:
Qingbo Wang would like to acknowledge the financial support from the China Scholarship Council (Student ID 201907960002 ) and KAUTE Foundation (Project number 20190031 ) to his doctoral study at Åbo Akademi University (ÅAU), Finland. Xiaoju Wang would like to thank Academy of Finland ( 333158 ) as well as Jane and Aatos Erkko Foundation for their funds to her research at ÅAU. This work is also part of activities within the Johan Gadolin Process Chemistry Centre (PCC) and has used the Aalto University Bioeconomy Facilities. Luyao Wang, Yury Brusentsev, and Sara Lund are respectively acknowledged for their technical assistance on TEM, NMR, and elemental analysis. Adrian Stiller and Jaana Paananen are acknowledged for their assistance on BaGNP dissolution experiments.
Funding Information:
Qingbo Wang would like to acknowledge the financial support from the China Scholarship Council (Student ID 201907960002) and KAUTE Foundation (Project number 20190031) to his doctoral study at ?bo Akademi University (?AU), Finland. Xiaoju Wang would like to thank Academy of Finland (333158) as well as Jane and Aatos Erkko Foundation for their funds to her research at ?AU. This work is also part of activities within the Johan Gadolin Process Chemistry Centre (PCC) and has used the Aalto University Bioeconomy Facilities. Luyao Wang, Yury Brusentsev, and Sara Lund are respectively acknowledged for their technical assistance on TEM, NMR, and elemental analysis. Adrian Stiller and Jaana Paananen are acknowledged for their assistance on BaGNP dissolution experiments.
Publisher Copyright:
© 2021 The Authors
PY - 2022/1/15
Y1 - 2022/1/15
N2 - We propose an injectable nanocomposite hydrogel that is photo-curable via light-induced thiol-ene addition between methacrylate modified O-acetyl-galactoglucomannan (GGMMA) and thiolated cellulose nanocrystal (CNC-SH). Compared to free-radical chain polymerization, the orthogonal step-growth of thiol-ene addition allows a less heterogeneous hydrogel network and more rapid crosslinking kinetics. CNC-SH reinforced the GGMMA hydrogel as both a nanofiller and a crosslinker to GGMMA resulting in an interpenetrating network via thiol-ene addition. Importantly, the mechanical stiffness of the GGMMA/CNC-SH hydrogel is mainly determined by the stoichiometric ratio between the thiol groups on CNC-SH and the methacrylate groups in GGMMA. Meanwhile, the bioactive glass nanoparticle (BaGNP)-laden hydrogels of GGMMA/CNC-SH showed a sustained release of therapeutic ions in simulated body fluid in vitro, which extended the bioactive function of hydrogel matrix. Furthermore, the suitability of the GGMMA/CNC-SH formulation as biomaterial resin to fabricate digitally designed hydrogel constructs via digital light processing (DLP) lithography printing was evaluated.
AB - We propose an injectable nanocomposite hydrogel that is photo-curable via light-induced thiol-ene addition between methacrylate modified O-acetyl-galactoglucomannan (GGMMA) and thiolated cellulose nanocrystal (CNC-SH). Compared to free-radical chain polymerization, the orthogonal step-growth of thiol-ene addition allows a less heterogeneous hydrogel network and more rapid crosslinking kinetics. CNC-SH reinforced the GGMMA hydrogel as both a nanofiller and a crosslinker to GGMMA resulting in an interpenetrating network via thiol-ene addition. Importantly, the mechanical stiffness of the GGMMA/CNC-SH hydrogel is mainly determined by the stoichiometric ratio between the thiol groups on CNC-SH and the methacrylate groups in GGMMA. Meanwhile, the bioactive glass nanoparticle (BaGNP)-laden hydrogels of GGMMA/CNC-SH showed a sustained release of therapeutic ions in simulated body fluid in vitro, which extended the bioactive function of hydrogel matrix. Furthermore, the suitability of the GGMMA/CNC-SH formulation as biomaterial resin to fabricate digitally designed hydrogel constructs via digital light processing (DLP) lithography printing was evaluated.
KW - Bioactive glass nanoparticles
KW - Galactoglucomannan methacrylate
KW - Photo-crosslinkable injectable hydrogels
KW - Thiol-ene chemistry
KW - Thiolated cellulose nanocrystal
UR - http://www.scopus.com/inward/record.url?scp=85120990213&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2021.118780
DO - 10.1016/j.carbpol.2021.118780
M3 - Article
AN - SCOPUS:85120990213
SN - 0144-8617
VL - 276
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 118780
ER -