In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

Chenyu Zong; Fei Wang; Wenguo Cui

doi:10.34133/research.0775

In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

Chenyu Zong
, Fei Wang^*
, Wenguo Cui^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel

2 Citeringar (Scopus)

2 Nedladdningar (Pure)

Sammanfattning

In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H₂, NO, and H₂S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H₂S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

Originalspråk	Engelska
Artikelnummer	0775
Tidskrift	Research
Volym	8
DOI	https://doi.org/10.34133/research.0775
Status	Publicerad - 2025
MoE-publikationstyp	B1 Artikel i en vetenskaplig tidskrift

Finansiering

Thanks to the Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine for their help.

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10.34133/research.0775Licens: CC BY

research.0775Slutlig publicerad version, 1,92 MBLicens: CC BY

https://urn.fi/URN:NBN:fi-fe2026022415850

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title = "In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems",

abstract = "In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system{\textquoteright}s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.",

author = "Chenyu Zong and Fei Wang and Wenguo Cui",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Chengyu Zong et al. Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works.",

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AU - Zong, Chenyu

AU - Wang, Fei

AU - Cui, Wenguo

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Y1 - 2025

N2 - In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

AB - In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

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In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

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