Improving the Sensitivity of Solid-Contact Ion-Selective Electrodes by Using Coulometric Signal Transduction

Tingting Han, Ulriika Mattinen, Johan Bobacka

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

23 Citeringar (Scopus)


A fundamental limitation of potentiometric ion sensors is their relatively low sensitivity due to the logarithmic dependence between potential and activity. Here we address this issue by exploring a recently developed coulometric transduction method for solid-contact ion-selective electrodes (SCISEs). Spin-coated thin-layer ion-selective membranes are used to lower the membrane resistance and shorten the response time of the SCISEs. When using coulometric transduction, an optimized design of the K+-SCISE is able to detect a concentration change of 5 mu M at a concentration level of 5 mM, corresponding to a 0.1% change in K+ activity. This indicates that SCISEs can provide extremely high sensitivity when employing coulometric transduction. Impedance measurements show that the coulometric transduction process for the K+-SCISE is limited by diffusion even for very thin ion-selective membranes. On the other hand, the H+-SCISE shows a low impedance and a fast coulometric response that is related to the high mobility of H+ in the H+-selective polymeric membrane as well as in the solid contact layer. The coulometric transduction method was used to detect small changes of pH in seawater and found to improve the sensitivity compared to classical potentiometry. The coulometric method was briefly tested also for determining activity changes of K+ in a serum sample.
Sidor (från-till)900–906
Antal sidor13
TidskriftACS Sensors
StatusPublicerad - 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad


  • pH
  • Solid-contact ISE
  • coulometric transduction
  • high sensitivity
  • seawater

Citera det här