Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases

John Eriksson, Diana Toivola, Jussi Meriluoto, H Karaki, YG Han, D Hartshorne

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    313 Citeringar (Scopus)


    The cyclic peptide hepatotoxins microcystin-LR, 7-desmethyl-microcystin-RR and nodularin are potent inhibitors of the protein phosphatases type 1 and type 2A. Their potency of inhibition resembles calyculin-A and to a lesser extent okadaic acid. These hepatotoxins increase the overall level of protein phosphorylation in hepatocytes. Evidence is presented to indicate that in hepatocytes the morphological changes and effects on the cytoskeleton are due to phosphatase inhibition. The potency of these compounds in inducing hepatocyte deformation is similar to their potency in inhibiting phosphatase activity. These results suggest that the hepatotoxicity of these peptides is related to inhibition of phosphatases, and further indicate the importance of the protein phosphorylation in maintenance of structural and homeostatic integrity in these cells.
    Sidor (från-till)1347–1353
    TidskriftBiochemical and Biophysical Research Communications
    StatusPublicerad - 1990
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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