Heat shock factors: integrators of cell stress, development and lifespan

M Åkerfelt, RI Morimoto, Lea Sistonen

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    861 Citeringar (Scopus)

    Sammanfattning

    Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)545–555
    Antal sidor11
    TidskriftNature Reviews Molecular Cell Biology
    Volym11
    Utgåva8
    DOI
    StatusPublicerad - 2010
    MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

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