Glycolipid transfer proteins

RE Brown, Peter Mattjus

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    64 Citeringar (Scopus)

    Sammanfattning

    Glycolipid transfer proteins (GLTPs) are small (24 kDa), soluble, ubiquitous proteins characterized by their ability to accelerate the intermembrane transfer of glycolipids in vitro. GLTP specificity encompasses both sphingoid- and glycerol-based glycolipids, but with a strict requirement that the initial sugar residue be beta-linked to the hydrophobic lipid backbone. The 3D architecture of GLTP reveals liganded structures with unique lipid-binding modes. The biochemical properties of GLTP action at the membrane surface have been studied rather comprehensively, but the biological role of GLTP remains enigmatic. What is clear is that GLTP differs distinctly from other known glycolipid-binding proteins, such as nonspecific lipid transfer proteins, lysosomal sphingolipid activator proteins, lectins, lung surfactant proteins as well as other lipid-binding/transfer proteins. Based on the unique conformational architecture that targets GLTP to membranes and enables glycolipid binding, GLTP is now considered the prototypical and founding member of a new protein superfamily in eukaryotes.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)746–760
    Antal sidor15
    TidskriftBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids
    Volym1771
    Utgåva6
    DOI
    StatusPublicerad - 2007
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Nyckelord

    • ACD11
    • cerebroside
    • cholesterol
    • FAPP2
    • ganglioside
    • GLTP
    • glycosphingolipid
    • HET-C2
    • lipid transfer protein structure
    • membrane interaction inotif
    • phosphatidyleholine
    • sphingomyelin

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