Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

Meiyan Wu; Wangfang Deng; Yidong Zhang; Chao Chen; Zhexuan Liu; Pedram Fatehi; Bin Li

doi:10.3390/polym14112286

Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

Meiyan Wu
, Wangfang Deng
, Yidong Zhang
, Chao Chen
, Zhexuan Liu
, Pedram Fatehi
, Bin Li^*

^*Korresponderande författare för detta arbete

Naturmaterialteknik

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

8 Citeringar (Scopus)

136 Nedladdningar (Pure)

Sammanfattning

It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.

Originalspråk	Engelska
Artikelnummer	2286
Tidskrift	Polymers
Volym	14
Nummer	11
DOI	https://doi.org/10.3390/polym14112286
Status	Publicerad - 4 juni 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

Funding: This work was financially supported by Shandong Provincial Natural Science Foundation for DistinguishedYoung Scholars(China) (Grant No.ZR2019JQ10),andQingdao independent innovation major project (Grant No.21-1-2-23-hz). Funding: This work was financially supported by Shandong Provincial Natural Science Foundation Author Contributions:M.W., investigation and writing-original draft preparation; W.D.,investiga-tionandmethodology;Y.Z.,investigation;C.C., investigation;Z.L., investigation;P.F.,methodology,writing-reviewing & editing;B.L., project administration, supervision, writing-reviewing & editing. All authors have read and agreed to the published version of the manuscript. This work was financially supported by Shandong Provincial Natural Science Foundation for Distinguished Young Scholars (China) (Grant No. ZR2019JQ10), and Qingdao independent innovation major project (Grant No. 21-1-2-23-hz).

Åtkomst av dokument

10.3390/polym14112286

polymers-14-02286Slutlig publicerad version, 3,03 MBLicens: CC BY

https://urn.fi/URN:NBN:fi-fe2023022228205

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@article{0a144518b18f4f75a62ab0c72e402185,

title = "Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers",

abstract = "It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4\%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0\%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.",

keywords = "cellulose nanofibrils, chitosan, drug carrier, drug release, tetracycline hydrochloride",

author = "Meiyan Wu and Wangfang Deng and Yidong Zhang and Chao Chen and Zhexuan Liu and Pedram Fatehi and Bin Li",

note = "Funding Information: Funding: This work was financially supported by Shandong Provincial Natural Science Foundation for DistinguishedYoung Scholars(China) (Grant No.ZR2019JQ10),andQingdao independent innovation major project (Grant No.21-1-2-23-hz). Funding Information: Funding: This work was financially supported by Shandong Provincial Natural Science Foundation Author Contributions:M.W., investigation and writing-original draft preparation; W.D.,investiga-tionandmethodology;Y.Z.,investigation;C.C., investigation;Z.L., investigation;P.F.,methodology,writing-reviewing \& editing;B.L., project administration, supervision, writing-reviewing \& editing. All authors have read and agreed to the published version of the manuscript. Funding Information: This work was financially supported by Shandong Provincial Natural Science Foundation for Distinguished Young Scholars (China) (Grant No. ZR2019JQ10), and Qingdao independent innovation major project (Grant No. 21-1-2-23-hz). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "4",

doi = "10.3390/polym14112286",

language = "English",

volume = "14",

journal = "Polymers",

issn = "2073-4360",

publisher = "MDPI",

number = "11",

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TY - JOUR

T1 - Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

AU - Wu, Meiyan

AU - Deng, Wangfang

AU - Zhang, Yidong

AU - Chen, Chao

AU - Liu, Zhexuan

AU - Fatehi, Pedram

AU - Li, Bin

N1 - Funding Information: Funding: This work was financially supported by Shandong Provincial Natural Science Foundation for DistinguishedYoung Scholars(China) (Grant No.ZR2019JQ10),andQingdao independent innovation major project (Grant No.21-1-2-23-hz). Funding Information: Funding: This work was financially supported by Shandong Provincial Natural Science Foundation Author Contributions:M.W., investigation and writing-original draft preparation; W.D.,investiga-tionandmethodology;Y.Z.,investigation;C.C., investigation;Z.L., investigation;P.F.,methodology,writing-reviewing & editing;B.L., project administration, supervision, writing-reviewing & editing. All authors have read and agreed to the published version of the manuscript. Funding Information: This work was financially supported by Shandong Provincial Natural Science Foundation for Distinguished Young Scholars (China) (Grant No. ZR2019JQ10), and Qingdao independent innovation major project (Grant No. 21-1-2-23-hz). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/4

Y1 - 2022/6/4

N2 - It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.

AB - It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.

KW - cellulose nanofibrils

KW - chitosan

KW - drug carrier

KW - drug release

KW - tetracycline hydrochloride

UR - https://www.scopus.com/pages/publications/85131853576

U2 - 10.3390/polym14112286

DO - 10.3390/polym14112286

M3 - Article

AN - SCOPUS:85131853576

SN - 2073-4360

VL - 14

JO - Polymers

JF - Polymers

IS - 11

M1 - 2286

ER -

Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

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