Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Didem Sen Karaman, Utku Kürşat Ercan, Emel Bakay, Nermin Topaloğlu, Jessica Rosenholm

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

8 Citeringar (Scopus)
13 Nedladdningar (Pure)

Sammanfattning

The threats posed by the impending “postantibiotic era” have put forward urgent challenges to be overcome by providing new diagnostic and therapeutic regimes for improved diagnosis and treatment of bacterial infections. Antibiotic resistance and incurable bacterial infections are especially important in a society faced with rapid demographic changes. With very few new antibiotics in the drug development pipeline, not being able to match the pace of antimicrobial resistance evolution, developments within other fields such as materials sciences and medical technologies are required to realize innovative antibacterial approaches. This progress report presents recent advances in especially nanotechnology-based approaches and their concomitant use with complementary antibacterial treatments. Synergistically improved antibacterial activity can be reached by considering novel, promising approaches such as photodynamic and photothermal therapy as well as cold atmospheric pressure treatments as complementary strategies to fight against antibacterial resistance. Moreover, this report describes how these novel technologies can be further improved especially by integration of nanomaterials into the currently applied single modal strategies against bacterial infections.
OriginalspråkEngelska
Artikelnummer1908783
Sidor (från-till)
TidskriftAdvanced Functional Materials
Volym30
Utgåva15
DOI
StatusPublicerad - 13 feb 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

Nyckelord

  • antibiotic resistance
  • Antimicrobial resistance (AMR)

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