Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding

AS Sahlberg, MA Penttinen, KM Heiskanen, RA Colbert, Lea Sistonen, K Granfors

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    17 Citeringar (Scopus)

    Sammanfattning

    Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)2652–2662
    Antal sidor11
    TidskriftArthritis and Rheumatism
    Volym56
    Utgåva8
    DOI
    StatusPublicerad - 2007
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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