Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans

Kaarina Ranta, Kaisa Nieminen, Filip S. Ekholm, Moniká Poláková, Mattias U.Roslund [Unknown], Tiina Saloranta, Reko Leino, Johannes Savolainen

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    25 Citeringar (Scopus)

    Sammanfattning

    Immunostimulatory properties of synthetic structures mimicking the beta-(1 -> 2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy) butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC).
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)1889–1893
    Antal sidor5
    TidskriftClinical and Vaccine Immunology
    Volym19
    Nummer11
    DOI
    StatusPublicerad - 2012
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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