Electrochemical detection of microcystins, cyanobacterial peptide hepatotoxins, following high-performance liquid chromatography

Jussi Meriluoto*, Brendan Kincaid, Malcolm R. Smyth, Mikael Wasberg

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

38 Citeringar (Scopus)

Sammanfattning

A novel amperometric HPLC detection method for the cyanobacterial (blue- green algal) peptide toxins microcystin-LR, -YR and -RR was developed. Purified microcystins and cyanobacterial extracts were chromatographed using an internal surface reversed-phase column with acetate- and phosphate-based mobile phase systems. Electrochemical oxidation reactions at 1.20 V vs. Ag/AgCl (glassy carbon working electrode) were shown to originate in arginine and tyrosine residues of microcystins.

OriginalspråkEngelska
Sidor (från-till)226-230
Antal sidor5
TidskriftJournal of Chromatography A
Volym810
Utgåva1-2
DOI
StatusPublicerad - 12 jun 1998
MoE-publikationstypA1 Tidskriftsartikel-refererad

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