Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS2nanosheets

Mohammed Zniber; Parastoo Vahdatiyekta; Shounak Roy; Kostiantyn Nikiforow; Amit Jaiswal; Tan-Phat Huynh

doi:10.1088/2399-1984/ac8215

Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS₂nanosheets

Mohammed Zniber
, Parastoo Vahdatiyekta
, Shounak Roy
, Kostiantyn Nikiforow
, Amit Jaiswal^*
, Tan-Phat Huynh^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

11 Citeringar (Scopus)

103 Nedladdningar (Pure)

Sammanfattning

Two-dimensional transition metal dichalcogenides have gained considerable attention from the scientific community for their various applications thanks to their remarkable chemical, physical, optical and electronic properties. In this study, MoS2 nanosheets were synthesized using a kitchen blender with the assistance of a surfactant, Pluronic F-127, through a shear-exfoliation process. The chemical composition, nanostructure and electrochemical properties of the synthesized MoS2-F127 were characterized by different methods. A Pt electrode modified with MoS2-F127 (Pt/MoS2-F127) was used with differential pulse voltammetry for the electrochemical detection of homovanillic acid (HVA) - a breast-cancer biomarker, in the presence of common interferents in urine. This study provides a new approach to discriminate the electrochemical signals of HVA and uric acid, leading to higher selectivity of the sensor.

Originalspråk	Engelska
Artikelnummer	035002
Tidskrift	Nano Futures
Volym	6
Nummer	3
DOI	https://doi.org/10.1088/2399-1984/ac8215
Status	Publicerad - 26 aug. 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

T-P H acknowledges the Liv och Hälsa Foundation and the Academy of Finland (Grant Nos. 323240 and 331774) for financial support. All authors acknowledge the INDFICORE (Indian Finnish Consortia for Research and Education). A J acknowledges the support from BioX centre and Advanced Materials Research Centre (AMRC), Indian Institute of Technology Mandi for research and infrastructure facility.

Åtkomst av dokument

10.1088/2399-1984/ac8215Licens: All rights reserved

MoS2-F127 manuscript - revised #2 clean versionAccepterat manuskript från författare, 2,23 MBLicens: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe20230901115091

Andra filer och länkar

Länk till publikationen i Scopus

FICORE: Finnish Indian Collaboration in Research and Education
Henelius, P. (Ansvarig forskare), Österbacka, R. (CoPI), De Blasio, C. (CoI), Salo-Ahen, O. (CoI), Huynh, T. P. (CoI), Yrjas, P. (CoI) & Saxén, H. (CoI)
Undervisnings och kulturministeriet i Finland (UKM)
01/01/21 → 31/12/24
Projekt: Ministerier / Statliga myndigheter och verk

Citera det här

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title = "Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS2nanosheets",

abstract = "Two-dimensional transition metal dichalcogenides have gained considerable attention from the scientific community for their various applications thanks to their remarkable chemical, physical, optical and electronic properties. In this study, MoS2 nanosheets were synthesized using a kitchen blender with the assistance of a surfactant, Pluronic F-127, through a shear-exfoliation process. The chemical composition, nanostructure and electrochemical properties of the synthesized MoS2-F127 were characterized by different methods. A Pt electrode modified with MoS2-F127 (Pt/MoS2-F127) was used with differential pulse voltammetry for the electrochemical detection of homovanillic acid (HVA) - a breast-cancer biomarker, in the presence of common interferents in urine. This study provides a new approach to discriminate the electrochemical signals of HVA and uric acid, leading to higher selectivity of the sensor.",

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note = "Funding Information: T-P H acknowledges the Liv och H{\"a}lsa Foundation and the Academy of Finland (Grant Nos. 323240 and 331774) for financial support. All authors acknowledge the INDFICORE (Indian Finnish Consortia for Research and Education). A J acknowledges the support from BioX centre and Advanced Materials Research Centre (AMRC), Indian Institute of Technology Mandi for research and infrastructure facility. Publisher Copyright: {\textcopyright} 2022 IOP Publishing Ltd.",

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AU - Vahdatiyekta, Parastoo

AU - Roy, Shounak

AU - Nikiforow, Kostiantyn

AU - Jaiswal, Amit

AU - Huynh, Tan-Phat

N1 - Funding Information: T-P H acknowledges the Liv och Hälsa Foundation and the Academy of Finland (Grant Nos. 323240 and 331774) for financial support. All authors acknowledge the INDFICORE (Indian Finnish Consortia for Research and Education). A J acknowledges the support from BioX centre and Advanced Materials Research Centre (AMRC), Indian Institute of Technology Mandi for research and infrastructure facility. Publisher Copyright: © 2022 IOP Publishing Ltd.

PY - 2022/8/26

Y1 - 2022/8/26

N2 - Two-dimensional transition metal dichalcogenides have gained considerable attention from the scientific community for their various applications thanks to their remarkable chemical, physical, optical and electronic properties. In this study, MoS2 nanosheets were synthesized using a kitchen blender with the assistance of a surfactant, Pluronic F-127, through a shear-exfoliation process. The chemical composition, nanostructure and electrochemical properties of the synthesized MoS2-F127 were characterized by different methods. A Pt electrode modified with MoS2-F127 (Pt/MoS2-F127) was used with differential pulse voltammetry for the electrochemical detection of homovanillic acid (HVA) - a breast-cancer biomarker, in the presence of common interferents in urine. This study provides a new approach to discriminate the electrochemical signals of HVA and uric acid, leading to higher selectivity of the sensor.

AB - Two-dimensional transition metal dichalcogenides have gained considerable attention from the scientific community for their various applications thanks to their remarkable chemical, physical, optical and electronic properties. In this study, MoS2 nanosheets were synthesized using a kitchen blender with the assistance of a surfactant, Pluronic F-127, through a shear-exfoliation process. The chemical composition, nanostructure and electrochemical properties of the synthesized MoS2-F127 were characterized by different methods. A Pt electrode modified with MoS2-F127 (Pt/MoS2-F127) was used with differential pulse voltammetry for the electrochemical detection of homovanillic acid (HVA) - a breast-cancer biomarker, in the presence of common interferents in urine. This study provides a new approach to discriminate the electrochemical signals of HVA and uric acid, leading to higher selectivity of the sensor.

KW - breast cancer

KW - electrochemical

KW - homovanillic acid

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KW - urine

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