Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

S Karvinen, M Silvennoinen, P Vainio, Lea Sistonen, LG Koch, SL Britton, H Kainulainen

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

15 Citeringar (Scopus)

Sammanfattning

Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.
OriginalspråkOdefinierat/okänt
Sidor (från-till)46–54
Antal sidor9
TidskriftExperimental Gerontology
Volym79
DOI
StatusPublicerad - 2016
MoE-publikationstypA1 Tidskriftsartikel-refererad

Nyckelord

  • aging
  • oxidative stress
  • physical activity
  • sirtuin
  • skeletal muscle

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