Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

S Karvinen; M Silvennoinen; P Vainio; Lea Sistonen; LG Koch; SL Britton; H Kainulainen

doi:10.1016/j.exger.2016.03.015

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

S Karvinen, M Silvennoinen, P Vainio, Lea Sistonen, LG Koch, SL Britton, H Kainulainen

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

28 Citeringar (Scopus)

Sammanfattning

Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.

Originalspråk	Odefinierat/okänt
Sidor (från-till)	46–54
Antal sidor	9
Tidskrift	Experimental Gerontology
Volym	79
DOI	https://doi.org/10.1016/j.exger.2016.03.015
Status	Publicerad - 2016
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Nyckelord

aging
oxidative stress
physical activity
sirtuin
skeletal muscle

Åtkomst av dokument

10.1016/j.exger.2016.03.015

Citera det här

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abstract = "Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.",

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T1 - Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

AU - Karvinen, S

AU - Silvennoinen, M

AU - Vainio, P

AU - Sistonen, Lea

AU - Koch, LG

AU - Britton, SL

AU - Kainulainen, H

PY - 2016

Y1 - 2016

N2 - Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.

AB - Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.

KW - aging

KW - oxidative stress

KW - physical activity

KW - sirtuin

KW - skeletal muscle

KW - aging

KW - oxidative stress

KW - physical activity

KW - sirtuin

KW - skeletal muscle

KW - aging

KW - oxidative stress

KW - physical activity

KW - sirtuin

KW - skeletal muscle

U2 - 10.1016/j.exger.2016.03.015

DO - 10.1016/j.exger.2016.03.015

M3 - Artikel

SN - 0531-5565

VL - 79

SP - 46

EP - 54

JO - Experimental Gerontology

JF - Experimental Gerontology

ER -