Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics

Mahmood Mazarei; Jan Åström; Jan Westerholm; Mikko Karttunen

doi:10.1103/PhysRevE.108.054405

Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics

Översatt titel: Inverkan av substratojämnheter och topologi på epitelvävnaders tillväxtdynamik

Mahmood Mazarei
, Jan Åström
, Jan Westerholm
, Mikko Karttunen

Informationsteknologi

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

5 Citeringar (Scopus)

Sammanfattning

Celltillväxt påverkas av egenskaperna och topologin hos underlaget som tillväxten sker på. VI simulerar cellvävnaders tillväxt på underlag med både fasta och svaga ojämnheter och kvantifierar den asymptotiska tillväxthastigheten hos vävnaden.

Översatt titel	Inverkan av substratojämnheter och topologi på epitelvävnaders tillväxtdynamik
Originalspråk	Engelska
Artikelnummer	054405
Tidskrift	Physical Review E
Volym	108
Nummer	5
DOI	https://doi.org/10.1103/PhysRevE.108.054405
Status	Publicerad - 13 nov. 2023
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Finansiering

M.K. thanks the Discovery and Canada Research Chairs Programs of the Natural Sciences and Engineering Research Council of Canada (NSERC) for financial support. M.M. thanks Western University's Science International Engagement Fund (SIEF) for travel support. Computational resources were provided by the Finnish Grid and Cloud Infrastructure FGCI, funded by the Academy of Finland, Grant No. 304973.

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molekyldynamik

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10.1103/PhysRevE.108.054405

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title = "Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics",

abstract = "Tissue growth kinetics and interface dynamics depend on the properties of the tissue environment and cell-cell interactions. In cellular environments, substrate heterogeneity and geometry arise from a variety factors, such as the structure of the extracellular matrix and nutrient concentration. We used the CellSim3D model, a kinetic cell division simulator, to investigate the growth kinetics and interface roughness dynamics of epithelial tissue growth on heterogeneous substrates with varying topologies. The results show that the presence of quenched disorder has a clear effect on the colony morphology and the roughness scaling of the interface in the moving interface regime. In a medium with quenched disorder, the tissue interface has a smaller interface roughness exponent, α, and a larger growth exponent, β. The scaling exponents also depend on the topology of the substrate and cannot be categorized by well-known universality classes.",

keywords = "molekyldynamik",

author = "Mahmood Mazarei and Jan {\AA}str{\"o}m and Jan Westerholm and Mikko Karttunen",

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year = "2023",

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TY - JOUR

T1 - Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics

AU - Mazarei, Mahmood

AU - Åström, Jan

AU - Westerholm, Jan

AU - Karttunen, Mikko

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PY - 2023/11/13

Y1 - 2023/11/13

N2 - Tissue growth kinetics and interface dynamics depend on the properties of the tissue environment and cell-cell interactions. In cellular environments, substrate heterogeneity and geometry arise from a variety factors, such as the structure of the extracellular matrix and nutrient concentration. We used the CellSim3D model, a kinetic cell division simulator, to investigate the growth kinetics and interface roughness dynamics of epithelial tissue growth on heterogeneous substrates with varying topologies. The results show that the presence of quenched disorder has a clear effect on the colony morphology and the roughness scaling of the interface in the moving interface regime. In a medium with quenched disorder, the tissue interface has a smaller interface roughness exponent, α, and a larger growth exponent, β. The scaling exponents also depend on the topology of the substrate and cannot be categorized by well-known universality classes.

AB - Tissue growth kinetics and interface dynamics depend on the properties of the tissue environment and cell-cell interactions. In cellular environments, substrate heterogeneity and geometry arise from a variety factors, such as the structure of the extracellular matrix and nutrient concentration. We used the CellSim3D model, a kinetic cell division simulator, to investigate the growth kinetics and interface roughness dynamics of epithelial tissue growth on heterogeneous substrates with varying topologies. The results show that the presence of quenched disorder has a clear effect on the colony morphology and the roughness scaling of the interface in the moving interface regime. In a medium with quenched disorder, the tissue interface has a smaller interface roughness exponent, α, and a larger growth exponent, β. The scaling exponents also depend on the topology of the substrate and cannot be categorized by well-known universality classes.

KW - molekyldynamik

U2 - 10.1103/PhysRevE.108.054405

DO - 10.1103/PhysRevE.108.054405

M3 - Article

SN - 1539-3755

VL - 108

JO - Physical Review E

JF - Physical Review E

IS - 5

M1 - 054405

ER -

Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics

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