Durable nanofibrous matrices augmented with hydrotalcite-like compounds for cutaneous regeneration of burn wounds

Mohan Vimala Devi, S.S. Liji Sobhana, Punalur John Shiny, Giriprasath Ramanathan, Sekar Jeyakumar Grace Felciya, Velswamy Poornima, Sathiah Thennarasu, Pedro Fardim, Uma Tiruchirapalli Sivagnanam*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

3 Citeringar (Scopus)

Sammanfattning

Electrospinning of Gelatin (G) and Poly-3-hydroxybutyric acid (P) incorporated with anionic drug (AgSD) loaded hydrotalcite (L) (L-AgSD) is carried out to fabricate a nanofibrous scaffold which would recreate the native extracellular matrix suitable for cutaneous regeneration. The L-AgSD complex was augmented into electrospun nanofibers of diameter 100–140 nm. The physiochemical (XRD, FTIR), morphological (SEM), mechanical (tensile strength) and biological (in vitro and in vivo) properties of the developed wound construct were studied. Antimicrobial studies reveal the potential activity against microbial infection. Studies on drug release kinetics demonstrate a controlled release of 86% in 72 h. In vitro biocompatibility studies using NIH 3T3 fibroblast cell line showed excellent cell adhesion and cell proliferation indicating the biocompatible nature of the scaffold. The matrix accelerated wound healing on Pseudomonas infected burn wound induced on rat models. The tailored matrix is promising as an impending nanohybrid construct for burn wound injuries with controlled drug release and antibacterial activity.
OriginalspråkEngelska
Artikelnummer105476
TidskriftApplied Clay Science
Volym187
DOI
StatusPublicerad - 1 feb 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

Fingeravtryck Fördjupa i forskningsämnen för ”Durable nanofibrous matrices augmented with hydrotalcite-like compounds for cutaneous regeneration of burn wounds”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här