Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

Laura Aalto-Setälä, Peter Uppstu, Polina Sinitsyna, Nina C. Lindfors, Leena Hupa*

*Korresponderande författare för detta arbete

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

10 Citeringar (Scopus)
54 Nedladdningar (Pure)

Sammanfattning

The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.
OriginalspråkEngelska
Artikelnummer4834
TidskriftMaterials
Volym14
Nummer17
DOI
StatusPublicerad - 26 aug. 2021
MoE-publikationstypA1 Tidskriftsartikel-refererad

Fingeravtryck

Fördjupa i forskningsämnen för ”Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här