Projekt per år
Lithography-based digital light processing (DLP) 3D printing has gained increasing interest in the fabrication of custom-designed hydrogel scaffolds. Current research development calls for the versatility of the bio-based resin formulations that deliver a suitable printability for fabricating biomedical hydrogel using DLP printing. Here, a bio-based antimicrobial resin was developed for DLP printing engaging the methacrylated O-acetyl-galactoglucomannan (GGMMA) as a photo-crosslinkable polymeric matrix and the nanocomposite lignin nanoparticles that are surface-embedded with silver nanoparticles (LNP@Ags) as a high-performance antimicrobial reagent. The alkali-resistance of LNPs as demanded for in situ reduction of silver nanoparticles (AgNPs) from silver ammonia solution (pH 11) was achieved by upgrading the technical lignin via a combination of lignin solvent fractionation with laccase-catalyzed polymerization. The dimension of the as-prepared LNPs (in the range of 120-290 nm) and the content of residual phenolic hydroxyl and methoxyl groups for reducing Ag + could be modulated by tuning the laccase-catalyzed lignin polymerization degree. The encapsulation of nanocomposite LNP@Ag into the GGMMA hydrogel did not significantly alter the gelation rate of the GGMMA/LNP@Ag resin and the mechanical property of the resulted hydrogel, when the dosage of LNP@Ag was less than 0.1 wt% in 10 wt% GGMMA. The GGMMA/LNP@Ag hydrogel also possesses high antimicrobial activity due to the bactericidal ability of Ag + that was leached out of the hydrogel in a sustained manner. Upon the layer-by-layer photocuring in DLP printing, the GGMMA/LNP@Ag resin allowed us to fabricate hydrogel constructs, including honeycomb and crosshatch with good structural stability and printing fidelity. This study proposes a green and effective fabrication route for LNP supported AgNPs as well as a novel case study for a sustainable resin suitable for DLP 3D hydrogel printing.
FingeravtryckFördjupa i forskningsämnen för ”Digital light processing (DLP) 3D-fabricated antimicrobial hydrogel with a sustainable resin of methacrylated woody polysaccharides and hybrid silver-lignin nanospheres”. Tillsammans bildar de ett unikt fingeravtryck.
Martti Toivakka (PI), Jessica Rosenholm (PI), Nicklas Anttu (PI), Johan Bobacka (PI), Tan Phat Huynh (PI), Jouko Peltonen (PI), Xiaoju Wang (PI), Carl-Eric Wilen (PI), Chunlin Xu (PI), Hongbo Zhang (PI) & Ronald Österbacka (PI)Fakulteten för naturvetenskaper och teknik
SusCellInk: Sustainable nanocellulose-based bioinks towards diverse material functionalities and therapeutic delivery of bioactive cues
01/09/20 → 31/08/25
Projekt: Finlands Akademi/Övriga Forskningsråd
01/09/21 → 31/08/23