Sammanfattning
Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.
Originalspråk | Odefinierat/okänt |
---|---|
Sidor (från-till) | 3012–3017 |
Antal sidor | 6 |
Tidskrift | Organometallics |
Volym | 32 |
Nummer | 10 |
DOI | |
Status | Publicerad - 2013 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |