Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, Reko Leino

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    4 Citeringar (Scopus)

    Sammanfattning

    Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.
    OriginalspråkOdefinierat/okänt
    Sidor (från-till)3012–3017
    Antal sidor6
    TidskriftOrganometallics
    Volym32
    Nummer10
    DOI
    StatusPublicerad - 2013
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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