Crosstalk between long noncoding RNA and microRNA in Cancer

Rahul Bhattacharjee, Neeraj Prabhakar, Lamha Kumar, Arkadyuti Bhattacharjee, Sulagna Kar, Sumira Malik, Dhruv Kumar, Janne Ruokolainen, Arvind Negi, Niraj Kumar Jha, Kavindra Kumar Kesari

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

13 Citeringar (Scopus)
4 Nedladdningar (Pure)

Sammanfattning

miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management.
OriginalspråkEngelska
Sidor (från-till)885-908
Antal sidor24
TidskriftCellular Oncology
Volym46
Nummer4
DOI
StatusPublicerad - aug. 2023
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

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