Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst: Bed dilution effects and cinchonidine adsorption study

E. Toukoniitty; P. Mäki-Arvela; N. Kumar; T. Salmi; D. Yu Murzin

doi:10.1023/B:CATL.0000027292.23132.5c

Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al₂O₃ catalyst: Bed dilution effects and cinchonidine adsorption study

E. Toukoniitty, P. Mäki-Arvela, N. Kumar, T. Salmi, D. Yu Murzin^*

^*Korresponderande författare för detta arbete

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

27 Citeringar (Scopus)

Sammanfattning

Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al₂O₃, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

Originalspråk	Engelska
Sidor (från-till)	179-183
Antal sidor	5
Tidskrift	Catalysis Letters
Volym	95
Nummer	3-4
DOI	https://doi.org/10.1023/B:CATL.0000027292.23132.5c
Status	Publicerad - juni 2004
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

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title = "Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst: Bed dilution effects and cinchonidine adsorption study",

abstract = "Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.",

keywords = "Adsorption of cinchonidine, Bed dilution, Continuous hydrogenation",

author = "E. Toukoniitty and P. M{\"a}ki-Arvela and N. Kumar and T. Salmi and Murzin, {D. Yu}",

year = "2004",

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doi = "10.1023/B:CATL.0000027292.23132.5c",

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volume = "95",

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journal = "Catalysis Letters",

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T1 - Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst

T2 - Bed dilution effects and cinchonidine adsorption study

AU - Toukoniitty, E.

AU - Mäki-Arvela, P.

AU - Kumar, N.

AU - Salmi, T.

AU - Murzin, D. Yu

PY - 2004/6

Y1 - 2004/6

N2 - Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

AB - Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

KW - Adsorption of cinchonidine

KW - Bed dilution

KW - Continuous hydrogenation

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JO - Catalysis Letters

JF - Catalysis Letters

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