Cellular stress response cross talk maintains protein and energy homeostasis

Cynthia L Swan; Lea Sistonen

doi:10.15252/embj.201490757

Cellular stress response cross talk maintains protein and energy homeostasis

Cynthia L Swan
, Lea Sistonen

Biokemi och cellbiologi

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

31 Citeringar (Scopus)

Sammanfattning

Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP-activated protein kinase (AMPK), the primary sensor in the metabolic stress response.

Originalspråk	Engelska
Sidor (från-till)	267–269
Antal sidor	3
Tidskrift	EMBO Journal
Volym	34
Nummer	3
DOI	https://doi.org/10.15252/embj.201490757
Status	Publicerad - 3 feb. 2015
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

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10.15252/embj.201490757

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abstract = "Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP-activated protein kinase (AMPK), the primary sensor in the metabolic stress response.",

keywords = "AMP-Activated Protein Kinases/metabolism, Animals, DNA-Binding Proteins/metabolism, Heat Shock Transcription Factors, Neoplasm Proteins/metabolism, Neoplasms, Experimental/metabolism, Stress, Physiological, Transcription Factors/metabolism",

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KW - AMP-Activated Protein Kinases/metabolism

KW - Animals

KW - DNA-Binding Proteins/metabolism

KW - Heat Shock Transcription Factors

KW - Neoplasm Proteins/metabolism

KW - Neoplasms, Experimental/metabolism

KW - Stress, Physiological

KW - Transcription Factors/metabolism

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Cellular stress response cross talk maintains protein and energy homeostasis

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