Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

Kalle T Rytkönen; Nigatu Adossa; Mehrad Mahmoudian; Tapio Lönnberg; Matti Poutanen; Laura L Elo

doi:10.1530/REP-22-0079

Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

Kalle T Rytkönen
, Nigatu Adossa
, Mehrad Mahmoudian
, Tapio Lönnberg
, Matti Poutanen
, Laura L Elo

Åbo biovetenskapscentrum

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

2 Citeringar (Scopus)

53 Nedladdningar (Pure)

Sammanfattning

Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

Originalspråk	Engelska
Sidor (från-till)	V9-V13
Antal sidor	5
Tidskrift	Reproduction
Volym	164
Nummer	5
DOI	https://doi.org/10.1530/REP-22-0079
Status	Publicerad - 1 nov. 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

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10.1530/REP-22-0079

rep-REP-22-0079Slutlig publicerad version, 2,59 MBLicens: CC BY

https://urn.fi/URN:NBN:fi-fe202403019374

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title = "Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia",

abstract = "IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.",

keywords = "Decidua/metabolism, Female, Humans, Killer Cells, Natural/metabolism, Pre-Eclampsia/metabolism, Pregnancy, Stromal Cells, Uterus",

author = "Rytk{\"o}nen, \{Kalle T\} and Nigatu Adossa and Mehrad Mahmoudian and Tapio L{\"o}nnberg and Matti Poutanen and Elo, \{Laura L\}",

year = "2022",

month = nov,

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doi = "10.1530/REP-22-0079",

language = "English",

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T1 - Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

AU - Rytkönen, Kalle T

AU - Adossa, Nigatu

AU - Mahmoudian, Mehrad

AU - Lönnberg, Tapio

AU - Poutanen, Matti

AU - Elo, Laura L

PY - 2022/11/1

Y1 - 2022/11/1

N2 - IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

AB - IN BRIEF: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.ABSTRACT: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

KW - Decidua/metabolism

KW - Female

KW - Humans

KW - Killer Cells, Natural/metabolism

KW - Pre-Eclampsia/metabolism

KW - Pregnancy

KW - Stromal Cells

KW - Uterus

U2 - 10.1530/REP-22-0079

DO - 10.1530/REP-22-0079

M3 - Article

C2 - 36111648

SN - 1470-1626

VL - 164

SP - V9-V13

JO - Reproduction

JF - Reproduction

IS - 5

ER -

Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

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